Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964874 | 0.86 | CHRM1 (0.59) | CHRM1L3MBTL1TP53TDP1PKM | |
| SCHEMBL16210842 | 0.85 | HPGD (0.46) | CHRM1HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL14964734 | 0.83 | CHRM1 (0.53) | CHRM1L3MBTL3L3MBTL1TP53TDP1 | |
| SCHEMBL14964967 | 0.77 | CHRM1 (0.57) | CHRM1L3MBTL1TP53TDP1PKM | |
| SCHEMBL16210661 | 0.76 | HPGD (0.47) | CHRM1TP53TDP1HRH3SMN1; SMN2 | |
| SCHEMBL14964841 | 0.75 | SMN1; SMN2 (0.51) | CHRM1L3MBTL3L3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL16210548 | 0.75 | SMN1; SMN2 (0.51) | CHRM1L3MBTL3L3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL3495072 | 0.72 | MEN1 (0.40) | L3MBTL3L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14978780 | 0.72 | CHRM1 (0.52) | CHRM1L3MBTL3L3MBTL1KCNH2HRH3 | |
| SCHEMBL2039482 | 0.72 | L3MBTL3 (0.39) | CHRM1L3MBTL3L3MBTL1TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780015-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | Heptares Therapeutics Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072705-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |