Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16210548 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBCHRM1TP53ALDH1A1 | |
| SCHEMBL16217913 | 0.88 | CHRM1 (0.52) | SMN1; SMN2POLBCHRM1TP53ALDH1A1 | |
| SCHEMBL28037969 | 0.85 | CHRM1 (0.56) | SMN1; SMN2POLBCHRM1TP53ALDH1A1 | |
| SCHEMBL485162 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2POLBTP53ALDH1A1GAA | |
| SCHEMBL18825113 | 0.83 | L3MBTL3 (0.45) | POLBCHRM1ALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL6032178 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2POLBCHRM1TP53ALDH1A1 | |
| SCHEMBL14978870 | 0.82 | HPGD (0.56) | SMN1; SMN2POLBCHRM1ALDH1A1OPRM1 | |
| SCHEMBL14978797 | 0.82 | HPGD (0.56) | SMN1; SMN2POLBCHRM1ALDH1A1OPRM1 | |
| SCHEMBL21837249 | 0.81 | CHRM1 (0.41) | CHRM1TP53ALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL21837251 | 0.81 | CHRM1 (0.41) | CHRM1TP53ALDH1A1L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793817-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2023-10-24 | — | — | US | disclosed |
| US-20210353637-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | NXERA PHARMA UK LIMITED (GB) | 2021-11-18 | — | — | US | disclosed |
| US-10973832-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2021-04-13 | — | — | US | disclosed |
| US-20200253982-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | NXERA PHARMA UK LIMITED (GB) | 2020-08-13 | — | — | US | disclosed |
| US-10413553-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2019-09-17 | — | — | US | disclosed |
| US-20180153900-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | NXERA PHARMA UK LIMITED (GB) | 2018-06-07 | — | — | US | disclosed |
| US-9907805-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2018-03-06 | — | — | US | disclosed |
| US-20170157139-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | NXERA PHARMA UK LIMITED (GB) | 2017-06-08 | — | — | US | disclosed |
| US-9573929-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2017-02-21 | — | — | US | disclosed |
| EP-2780015-B1 | MUSCARINIC M1 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LTD (GB) | 2017-01-04 | — | — | EP | disclosed |
| US-20160068508-A1 | Muscarinic M1 Receptor Agonists | NXERA PHARMA UK LIMITED (GB) | 2016-03-10 | — | — | US | disclosed |
| US-9187451-B2 | Muscarinic M1 receptor agonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20140329803-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | NXERA PHARMA UK LIMITED (GB) | 2014-11-06 | — | — | US | disclosed |
| EP-2780015-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | Heptares Therapeutics Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072705-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329803-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-20180153900-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-20160068508-A1 | Muscarinic M1 Receptor Agonists | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-20200253982-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-20210353637-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-20170157139-A1 | MUSCARINIC M1 RECEPTOR AGONISTS | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-10973832-B2 | Muscarinic M1 receptor agonists | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-10413553-B2 | Muscarinic M1 receptor agonists | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
| US-11793817-B2 | Muscarinic M1 receptor agonists | CHRM1, CHRM2, CHRM3 | SMN1; SMN2 1295/4885POLB 3645/4885CHRM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.