Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21933632 | 0.88 | HRH3 (0.33) | SIGMAR1HTR2AHTR2BHRH3 | |
| SCHEMBL17451649 | 0.81 | CYP1A2 (0.42) | CYP2D6CYP1A2SIGMAR1CYP3A4ALDH1A1 | |
| SCHEMBL21933629 | 0.79 | HRH3 (0.36) | SIGMAR1ALDH1A1MAPK1HTR2AHTR2B | |
| SCHEMBL13741087 | 0.79 | HRH3 (0.43) | CYP1A2SIGMAR1TSHRKCNH2ALDH1A1 | |
| SCHEMBL21933934 | 0.78 | SIGMAR1 (0.33) | SIGMAR1HTR2AHTR2BHRH3 | |
| SCHEMBL16293179 | 0.78 | RECQL (0.54) | SMN1; SMN2USP2 | |
| SCHEMBL24856304 | 0.77 | HRH3 (0.32) | HRH3 | |
| SCHEMBL13741195 | 0.77 | HRH3 (0.40) | CYP1A2SIGMAR1TSHRKCNH2ALDH1A1 | |
| SCHEMBL19370316 | 0.77 | TDP1 (0.40) | CYP2D6CYP1A2SIGMAR1TSHRKCNH2 | |
| SCHEMBL21025893 | 0.76 | DRD2 (0.33) | SIGMAR1ALDH1A1HTR2AHTR2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |