Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9611075 | 0.85 | GNAO1 (0.34) | CYP1A2 | |
| SCHEMBL17282107 | 0.84 | THRB (0.42) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6448305 | 0.83 | NCF1 (0.43) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL13007658 | 0.83 | CYP1A2 (0.44) | CYP1A2SIGMAR1 | |
| SCHEMBL8233850 | 0.82 | ALDH1A1 (0.46) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL23317131 | 0.81 | ALDH1A1 (0.44) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL13007653 | 0.81 | CYP1A2 (0.47) | CYP1A2SIGMAR1 | |
| SCHEMBL13007656 | 0.81 | NCF1 (0.38) | CYP1A2SIGMAR1 | |
| SCHEMBL14965200 | 0.81 | CYP2D6 (0.40) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL10188202 | 0.81 | ALDH1A1 (0.50) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016945-A1 | SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | NANTBIO, INC. | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016945-A1 | SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | GRK5, GRK3, CDK5 | CYP1A2 2848/4885CYP2D6 3182/4885SMN1; SMN2 2712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.