Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965368 | 0.97 | KCNJ1 (0.40) | KCNJ1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14971065 | 0.88 | SLC2A1 (0.41) | KCNJ1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14965560 | 0.88 | HIF1A (0.40) | KCNJ1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14966002 | 0.88 | HPGD (0.54) | ALDH1A1SMN1; SMN2PKMNPSR1MEN1 | |
| SCHEMBL14965773 | 0.88 | L3MBTL1 (0.46) | KCNJ1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14965626 | 0.88 | LTA4H (0.40) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL14965511 | 0.88 | LTA4H (0.40) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL14965793 | 0.87 | HPGD (0.53) | KCNJ1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14965777 | 0.87 | HIF1A (0.58) | ALDH1A1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL14966317 | 0.86 | LOXL2 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |