Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965630 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL8310353 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL2934603 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL2934605 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL993398 | 0.80 | TSHR (0.45) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL13176444 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| SCHEMBL2401928 | 0.78 | — | — | |
| SCHEMBL167805 | 0.78 | — | — | |
| Maleic Acid SCHEMBL713343 | 0.78 | TSHR (0.64) | ALDH1A1TSHRTDP1ALOX15RECQL | |
| Maleic Acid SCHEMBL6052835 | 0.78 | TSHR (0.64) | ALDH1A1TSHRTDP1ALOX15RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598393-B2 | Structural variants of mycolactones for use in modulating inflammation, immunity and pain | INSTITUT PASTEUR (FR) | 2017-03-21 | — | — | US | claimed |
| EP-2780336-B1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | PASTEUR INSTITUT (FR) | 2017-07-19 | — | — | EP | disclosed |
| EP-2780336-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | Institut Pasteur (FR) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072896-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | INSTITUT PASTEUR (FR) | 2013-05-23 | — | — | WO | disclosed |