SCHEMBL993398

SCHEMBL993398

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nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.45
TP53 P04637 2/20 0.45
EGLN1 Q9GZT9 1/20 0.45
EGLN3 Q9H6Z9 1/20 0.45
ALDH1A1 P00352 6/20 0.38
TDP1 Q9NUW8 3/20 0.38
ALOX15 P16050 2/20 0.38
RECQL P46063 2/20 0.38
HSD17B10 Q99714 2/20 0.38
HCAR2 Q8TDS4 4/20 0.37
LMNA P02545 3/20 0.33
GABRR1 P24046 2/20 0.33
GABRR2 P28476 2/20 0.33
BLM P54132 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
GAA P10253 1/20 0.33
GABRR3 A8MPY1 1/20 0.33
APEX1 P27695 1/20 0.33
POLB P06746 1/20 0.32
GABRP O00591 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14965630 0.80 ALDH1A1 (0.48) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL14965632 0.80 ALDH1A1 (0.48) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL2401928 0.78
SCHEMBL167805 0.78
Fumaric Acid SCHEMBL6871005 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1
Fumaric Acid SCHEMBL1024373 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1
Maleic Acid SCHEMBL342490 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1
Fumaric Acid SCHEMBL342492 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1
Maleic Acid SCHEMBL713343 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1
Maleic Acid SCHEMBL6052835 0.78 TSHR (0.64) TSHRTP53EGLN1EGLN3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110008265-A1 In Situ Polymerization For Hair Treatment LIVING PROOF, INC. (US) 2011-01-13 US disclosed
WO-2007127065-A9 IN SITU POLYMERIZATION FOR HAIR TREATMENT ANDORA INC (US) 2008-07-31 WO disclosed
US-20080066773-A1 IN SITU POLYMERIZATION FOR HAIR TREATMENT LIVING PROOF, INC. 2008-03-20 US disclosed
WO-2007127065-A2 IN SITU POLYMERIZATION FOR HAIR TREATMENT LIVING PROOF, INC. (US) 2007-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080066773-A1 IN SITU POLYMERIZATION FOR HAIR TREATMENT PPOX, SUCLG1, GFER TSHR 3502/4885TP53 1703/4885EGLN1 765/4885
US-20110008265-A1 In Situ Polymerization For Hair Treatment PPOX, SUCLG1, GFER TSHR 3539/4885TP53 1680/4885EGLN1 877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.