Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965901 | 0.87 | MITF (0.37) | MITFPOLBLMNAALDH1A1CYP1A2 | |
| SCHEMBL14965850 | 0.85 | MITF (0.35) | MITFPOLBLMNA | |
| SCHEMBL14965734 | 0.83 | NR1D1 (0.38) | MITFLMNAALDH1A1 | |
| SCHEMBL14971154 | 0.82 | MITF (0.34) | MITFPOLBLMNAKMT2AALDH1A1 | |
| SCHEMBL14965596 | 0.82 | MITF (0.38) | MITFLMNAKMT2AALDH1A1 | |
| SCHEMBL14969412 | 0.81 | NR1D1 (0.36) | MITFPOLBALDH1A1 | |
| SCHEMBL14969675 | 0.81 | ALDH1A1 (0.33) | MITFPOLBLMNAKMT2AALDH1A1 | |
| SCHEMBL14969684 | 0.81 | NR1D1 (0.36) | MITFLMNAALDH1A1 | |
| SCHEMBL14966256 | 0.80 | MITF (0.43) | MITFLMNAKMT2AALDH1A1 | |
| SCHEMBL14965539 | 0.80 | NR1H3 (0.39) | MITFKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |