Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966152 | 0.92 | ALDH1A1 (0.51) | HIF1AEPAS1CHRM1KCNH2ABL1 | |
| SCHEMBL14966248 | 0.91 | HIF1A (0.51) | HIF1AEPAS1CHRM1KCNH2ABL1 | |
| SCHEMBL14965964 | 0.89 | HIF1A (0.52) | HIF1AEPAS1ALDH1A1MEN1KMT2A | |
| SCHEMBL14965916 | 0.88 | ABL1 (0.56) | HIF1AEPAS1CHRM1KCNH2ABL1 | |
| SCHEMBL14965884 | 0.86 | CHRM1 (0.46) | CHRM1KCNH2ABL1ALDH1A1MEN1 | |
| SCHEMBL14965557 | 0.84 | DRD4 (0.48) | CHRM1KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL14965927 | 0.84 | ALDH1A1 (0.52) | HIF1AEPAS1ALDH1A1MEN1KMT2A | |
| SCHEMBL14965784 | 0.83 | CHRM1 (0.49) | CHRM1KCNH2ABL1ALDH1A1HPGD | |
| SCHEMBL14965959 | 0.83 | KCNH2 (0.53) | HIF1AEPAS1CHRM1KCNH2ABL1 | |
| SCHEMBL14966147 | 0.83 | KCNH2 (0.53) | HIF1AEPAS1CHRM1KCNH2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |