Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965916 | 0.93 | ABL1 (0.56) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14965787 | 0.92 | HIF1A (0.44) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14965927 | 0.92 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14966147 | 0.91 | KCNH2 (0.53) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14965959 | 0.91 | KCNH2 (0.53) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14969414 | 0.90 | LMNA (0.53) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14965591 | 0.89 | CHRM3 (0.47) | ALDH1A1KMT2AMEN1ABL1KCNH2 | |
| SCHEMBL14966245 | 0.89 | MEN1 (0.53) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14965884 | 0.88 | CHRM1 (0.46) | ALDH1A1KMT2AMEN1ABL1KCNH2 | |
| SCHEMBL14965557 | 0.86 | DRD4 (0.48) | ALDH1A1KMT2AMEN1KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |