Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966246 | 0.94 | GLS (0.44) | BRD4GLSPTGS2G6PDTLR9 | |
| SCHEMBL5864145 | 0.84 | ALDH1A1 (0.46) | GLSPOLBRAB9AMEN1KMT2A | |
| SCHEMBL5429188 | 0.82 | GLS (0.60) | CNR2BRD4GLSRIPK1POLB | |
| SCHEMBL14966121 | 0.82 | BRD4 (0.46) | BRD4NPBWR1PTGS1PTGS2PDE1A | |
| SCHEMBL14966507 | 0.80 | SIRT2 (0.44) | RIPK1POLBRAB9ASIRT2HSP90AA1 | |
| SCHEMBL3384221 | 0.78 | GLS (0.50) | BRD4GLS | |
| SCHEMBL9874375 | 0.78 | GLS (0.50) | GLSPOLBRAB9AG6PDTLR9 | |
| SCHEMBL7805916 | 0.77 | BRD4 (0.43) | CNR2BRD4GLSRIPK1POLB | |
| SCHEMBL14966310 | 0.76 | SIRT2 (0.40) | GLSPDE1CRIPK1POLBRAB9A | |
| SCHEMBL14966684 | 0.76 | GLS (0.45) | GLSPTGS2POLBG6PDTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |