Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013953 | 0.88 | CHEK1 (0.44) | BPTFMETBRPF1CHEK1AURKA | |
| SCHEMBL29702303 | 0.82 | BRD4 (0.41) | ALDH1A1KDM4EHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL1375296 | 0.82 | BRD4 (0.41) | ALDH1A1KDM4EHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL29380296 | 0.81 | HTR2A (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9ATYMS | |
| SCHEMBL29702195 | 0.81 | BPTF (0.43) | BPTFALDH1A1KDM4ETYMSKAT2B | |
| SCHEMBL14966529 | 0.78 | CHEK1 (0.39) | BPTFMETBRPF1CHEK1AURKA | |
| SCHEMBL22971729 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL29702224 | 0.78 | TXNRD1 (0.44) | AURKAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL22995156 | 0.77 | CCNC (0.42) | BPTFALDH1A1HSD17B10CA12CA9 | |
| SCHEMBL14965963 | 0.76 | L3MBTL1 (0.50) | ALDH1A1MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |