Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967302 | 0.87 | MAPT (0.62) | PKMPOLBKMT2AMAPTRAB9A | |
| SCHEMBL14967291 | 0.87 | MRGPRX4 (0.54) | PKMPOLBKMT2AMAPTGAA | |
| SCHEMBL14966650 | 0.85 | MAOB (0.61) | PKMPOLBCASP6PTGER4RAB9A | |
| SCHEMBL14966652 | 0.82 | PKM (0.61) | PKMPOLBCASP6KMT2APTGER4 | |
| SCHEMBL14966439 | 0.82 | PKM (0.57) | PKMPOLBCASP6KMT2APTGER4 | |
| SCHEMBL14967211 | 0.82 | PTGER4 (0.49) | PKMPOLBCASP6KMT2APTGER4 | |
| SCHEMBL11328385 | 0.82 | PKM (0.60) | PKMPOLBCASP6KMT2AMAPT | |
| SCHEMBL29145227 | 0.78 | RARB (0.51) | PKMMAPTTP53TSHRPLA2G4B | |
| SCHEMBL11423248 | 0.77 | EPHX2 (0.51) | KMT2ATSHRSMN1; SMN2L3MBTL1GAA | |
| SCHEMBL11424107 | 0.77 | EPHX2 (0.51) | KMT2ATSHRSMN1; SMN2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |