Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18703605 | 0.87 | PTGER4 (0.46) | PTGER4ALDH1A1PKMRAB9AMAPT | |
| SCHEMBL14966397 | 0.82 | PKM (0.57) | PTGER4PKMRAB9AMAPTPOLB | |
| SCHEMBL14966861 | 0.79 | FFAR1 (0.50) | PTGER4ALDH1A1PKMRAB9AMAPT | |
| SCHEMBL11328385 | 0.79 | PKM (0.60) | ALDH1A1PKMRAB9AMAPTPOLB | |
| SCHEMBL10727229 | 0.77 | PTGER4 (0.47) | PTGER4ALDH1A1PKMRAB9APOLB | |
| SCHEMBL20541672 | 0.77 | ALDH1A1 (0.47) | PTGER4ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL14967302 | 0.76 | MAPT (0.62) | ALDH1A1PKMRAB9AMAPTPOLB | |
| SCHEMBL18703595 | 0.76 | MAPT (0.51) | PTGER4ALDH1A1RAB9AMAPTPOLB | |
| SCHEMBL19194681 | 0.75 | NR4A2 (0.54) | PTGER4RAB9APOLBNPC1LMNA | |
| SCHEMBL10721956 | 0.75 | ALDH1A1 (0.50) | PTGER4ALDH1A1PKMRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |