Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966988 | 0.86 | MAPT (0.65) | PKMPOLBPARP10MAPTRAB9A | |
| SCHEMBL14966439 | 0.82 | PKM (0.57) | PKMPOLBCASP6PARP10PLA2G4B | |
| SCHEMBL14966397 | 0.82 | PKM (0.57) | PKMPOLBCASP6PARP10PLA2G4B | |
| SCHEMBL11328385 | 0.82 | PKM (0.60) | PKMPOLBCASP6PARP10PLA2G4B | |
| SCHEMBL1285278 | 0.77 | PKM (1.00) | PKMPOLBCASP6PARP10PLA2G4B | |
| SCHEMBL14967007 | 0.77 | PDPK1 (0.47) | RAB9AKMT2A | |
| SCHEMBL12544848 | 0.76 | PKM (0.56) | PKMPOLBCASP6PARP10PLA2G4B | |
| SCHEMBL9952644 | 0.76 | RXRA (0.49) | POLBTP53TSHRMAPTRAB9A | |
| SCHEMBL3649295 | 0.76 | HTR7 (0.54) | POLBTP53TSHRMAPTRAB9A | |
| SCHEMBL16368720 | 0.76 | PKM (0.65) | PKMPARP10PLA2G4BTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |