Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EEF2 | P13639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969018 | 0.86 | IKBKB (0.39) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14968867 | 0.83 | IKBKB (0.39) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14969065 | 0.83 | IKBKB (0.41) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14968923 | 0.80 | IKBKB (0.38) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14969017 | 0.79 | IKBKB (0.38) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14969052 | 0.77 | IKBKB (0.36) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14968912 | 0.76 | RCE1 (0.38) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14968966 | 0.74 | IKBKB (0.41) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14969024 | 0.74 | RCE1 (0.36) | IKBKBKDM4EALDH1A1GLAGAA | |
| SCHEMBL14968934 | 0.73 | CDK8 (0.40) | IKBKBKDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | disclosed |