Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EEF2 | P13639 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14968935 | 0.81 | EEF2K (0.46) | RCE1EEF2KALDH1A1KDM4EKMT2A | |
| SCHEMBL14968912 | 0.75 | RCE1 (0.38) | CDK8CDK19RCE1EEF2KALDH1A1 | |
| SCHEMBL14966609 | 0.73 | IKBKB (0.41) | CDK8CDK19RCE1EEF2KALDH1A1 | |
| SCHEMBL14969024 | 0.73 | RCE1 (0.36) | RCE1EEF2KALDH1A1KDM4EIKBKB | |
| SCHEMBL14969004 | 0.71 | IKBKB (0.36) | RCE1EEF2KALDH1A1KDM4EIKBKB | |
| SCHEMBL11727213 | 0.70 | KDM4E (0.69) | ALDH1A1KDM4EKMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL14969095 | 0.69 | ENPP1 (0.40) | RCE1EEF2KALDH1A1KDM4EIKBKB | |
| SCHEMBL14966299 | 0.69 | RCE1 (0.44) | RCE1EEF2KALDH1A1KDM4EIKBKB | |
| SCHEMBL22717021 | 0.68 | CDK8 (0.47) | CDK8CDK19ALDH1A1KDM4EKMT2A | |
| SCHEMBL3536841 | 0.68 | POLB (0.46) | CDK8CDK19ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | disclosed |