Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 9/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 9/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.47 |
| ▸ | HNF4A | P41235 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730751 | 0.95 | PRKAG1 (0.48) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL25680334 | 0.91 | TSHR (0.48) | HNF4AHPGDTP53TSHRMEN1 | |
| SCHEMBL18394292 | 0.84 | KMT2A (0.54) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL19662088 | 0.82 | KCNH2 (0.50) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL23662444 | 0.80 | NPC1 (0.58) | HNF4AHPGDTP53TSHRKMT2A | |
| SCHEMBL13374166 | 0.79 | CYP2C9 (0.49) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL4444258 | 0.79 | TSHR (0.54) | HPGDTP53TSHRALDH1A1 | |
| SCHEMBL6421056 | 0.78 | TSHR (0.46) | HNF4APOLBHPGDTP53TSHR | |
| SCHEMBL6866533 | 0.77 | ESR2 (0.45) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL7189606 | 0.77 | PRKAG1 (0.43) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-20140288123-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2014-09-25 | — | — | US | disclosed |
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288123-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TET1, TET3, EHMT2 | PRKAG1 386/4885PRKAA1 758/4885PRKAB1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.