Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730751 | 0.85 | PRKAG1 (0.48) | HPGDPRKAG1PRKAA1PRKAB1PRKAA2 | |
| SCHEMBL7189606 | 0.81 | PRKAG1 (0.43) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL14966664 | 0.79 | PRKAG1 (0.47) | HPGDPRKAG1PRKAA1PRKAB1PRKAA2 | |
| SCHEMBL18394292 | 0.78 | KMT2A (0.54) | HPGDPRKAG1PRKAA1PRKAB1PRKAA2 | |
| SCHEMBL27656111 | 0.77 | KCNH2 (0.46) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL14300774 | 0.77 | KCNH2 (0.41) | HPGDPRKAG1PRKAA1PRKAB1PRKAA2 | |
| SCHEMBL6439299 | 0.76 | RAB9A (0.55) | CYP2C9HPGD | |
| SCHEMBL19662088 | 0.75 | KCNH2 (0.50) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL17963141 | 0.74 | HDAC8 (0.61) | CYP2C9PARP10PARP15PARP2 | |
| SCHEMBL20684259 | 0.74 | HPGD (0.40) | CYP2C9HPGDPARP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288383-B2 | 3-methyl-2- ( (2S) -2- (4- (3-methyl-L, 2, 4-oxadiazol-5-YL) phenyl) morpholino) -6- (pyrim-idin-4-yl) pyrimidin-4 (3H) -one as tau protein kinase inhibitor | SANOFI (FR) | 2012-10-16 | — | — | US | disclosed |