Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 8/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL14966447 | 0.86 | HRH4 (0.31) | GPR119HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL16163342 | 0.79 | GPR119 (0.38) | GPR119KCNH2DPP4DPP7CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL14966698 | 0.77 | GPR119 (0.43) | GPR119KCNH2DPP4DPP7CYP2D6 | |
| SCHEMBL5499551 | 0.76 | PLAT (0.35) | GPR119 | |
| SCHEMBL14966419 | 0.75 | KCNH2 (0.43) | GPR119KCNH2 | |
| Trifluoroacetic Acid SCHEMBL16163282 | 0.75 | GPR119 (0.40) | GPR119KCNH2DPP4DPP7CYP2D6 | |
| SCHEMBL16163343 | 0.71 | GPR119 (0.36) | GPR119KCNH2ELANE | |
| SCHEMBL16169607 | 0.69 | GPR119 (0.37) | GPR119KCNH2CYP2D6ELANE | |
| Trifluoroacetic Acid SCHEMBL15665857 | 0.69 | GPR119 (0.56) | GPR119KCNH2 | |
| Trifluoroacetic Acid SCHEMBL4436898 | 0.68 | OPRM1 (0.52) | KCNH2DPP4DPP7CYP2D6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |