Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MMP10 | P09238 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966576 | 0.92 | KLKB1 (0.43) | KMT2AMMP10MMP8MMP13PPARG | |
| SCHEMBL14966474 | 0.91 | MAPK14 (0.44) | RAB9AKMT2APPARGLMNANPC1 | |
| SCHEMBL14966879 | 0.90 | MAPK14 (0.39) | KMT2APPARGLMNAHDAC1MAPK14 | |
| SCHEMBL14966647 | 0.87 | SCN9A (0.44) | RAB9AMMP13PPARGLMNAHPGD | |
| SCHEMBL14969436 | 0.87 | MAPK14 (0.44) | RAB9AKMT2AMMP13PPARGNPC1 | |
| SCHEMBL14966659 | 0.86 | LMNA (0.48) | RAB9AKMT2APPARGLMNAHPGD | |
| SCHEMBL14966459 | 0.84 | KLKB1 (0.40) | KMT2AMMP10MMP8MMP13LMNA | |
| SCHEMBL14966598 | 0.84 | KLKB1 (0.44) | MMP10MMP8MMP13LMNA | |
| SCHEMBL14967153 | 0.84 | KDM4E (0.40) | RAB9AKMT2APPARGLMNAHPGD | |
| SCHEMBL14966830 | 0.84 | KLKB1 (0.44) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |