Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MMP10 | P09238 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967153 | 0.89 | KDM4E (0.40) | KLKB1MAP4K1LMNARECQLSMN1; SMN2 | |
| SCHEMBL14966659 | 0.88 | LMNA (0.48) | KLKB1LMNASMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL14966830 | 0.87 | KLKB1 (0.44) | KLKB1MAP4K1RECQLSMN1; SMN2KDM4E | |
| SCHEMBL14967113 | 0.87 | LMNA (0.50) | LMNARECQLSMN1; SMN2MMP13 | |
| SCHEMBL14966474 | 0.87 | MAPK14 (0.44) | LMNASMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL14966879 | 0.86 | MAPK14 (0.39) | KLKB1MAP4K1LMNASMN1; SMN2KDM4E | |
| SCHEMBL14966778 | 0.86 | NPC1 (0.49) | LMNASMN1; SMN2MMP13 | |
| SCHEMBL14966398 | 0.85 | POLB (0.52) | KLKB1LMNASMN1; SMN2HPGDMEN1 | |
| SCHEMBL14966647 | 0.85 | SCN9A (0.44) | LMNASMN1; SMN2MMP13HPGDHSD17B10 | |
| SCHEMBL14966935 | 0.84 | RAB9A (0.46) | LMNAMMP10MMP8MMP13HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |