Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966459 | 0.89 | KLKB1 (0.40) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL14967111 | 0.88 | LMNA (0.39) | SMN1; SMN2KLKB1MAP4K1LMNAMAPK14 | |
| SCHEMBL14966659 | 0.87 | LMNA (0.48) | HPGDHSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14966474 | 0.86 | MAPK14 (0.44) | KDM4EMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL14966879 | 0.85 | MAPK14 (0.39) | KDM4EMEN1KMT2ASMN1; SMN2KLKB1 | |
| SCHEMBL14966830 | 0.85 | KLKB1 (0.44) | KDM4EMEN1KMT2ASMN1; SMN2KLKB1 | |
| SCHEMBL14967113 | 0.84 | LMNA (0.50) | SMN1; SMN2LMNAMAPK14RECQLNPC1 | |
| SCHEMBL14966935 | 0.84 | RAB9A (0.46) | HPGDHSD17B10KMT2ALMNAMAPK14 | |
| SCHEMBL14966781 | 0.83 | RAB9A (0.47) | KDM4EHPGDSMN1; SMN2KLKB1LMNA | |
| SCHEMBL14966778 | 0.83 | NPC1 (0.49) | SMN1; SMN2LMNAALDH1A1MAPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |