Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426463 | 0.79 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17465569 | 0.79 | MAPT (0.39) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29176987 | 0.79 | MAPT (0.39) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22884505 | 0.78 | MAPT (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14955914 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5425809 | 0.75 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17404934 | 0.75 | MAPT (0.36) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2565629 | 0.75 | ALDH1A1 (0.53) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9119019 | 0.74 | MAPT (0.38) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1458409 | 0.74 | TSHR (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967519-B1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2011-09-01 | — | — | US | disclosed |
| US-7906508-B2 | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity | JAPAN TOBACCO INC. (JP) | 2011-03-15 | — | — | US | disclosed |
| EP-1967519-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | MAPT 4791/4885ALDH1A1 1012/4885MEN1 4733/4885 |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | MAPT 4791/4885ALDH1A1 1012/4885MEN1 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.