SCHEMBL14967944

SCHEMBL14967944

Cc1ccc(C2(C(=O)OC(C)(C)C)OC23CCCCC3)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.36
KDM4E B2RXH2 1/20 0.33
HPGD P15428 1/20 0.33
HTR1E P28566 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
S1PR3 Q99500 1/20 0.33
OPRM1 P35372 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
GPR119 Q8TDV5 1/20 0.32
POLB P06746 2/20 0.32
CYP3A4 P08684 2/20 0.31
CYP2C9 P11712 2/20 0.31
CYP2C19 P33261 2/20 0.31
AKR1B1 P15121 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14968351 0.99 MAPT (0.36) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14967473 0.96 OPRM1 (0.34) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14967469 0.88 AKR1C1 (0.38) SMN1; SMN2ALDH1A1POLBCYP3A4CYP2C9
SCHEMBL14968200 0.87 SLC6A4 (0.42) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14966595 0.86 AKR1C1 (0.39) ALDH1A1KDM4EPOLBCYP3A4LMNA
SCHEMBL14967508 0.85 CYP3A4 (0.41) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14966832 0.85 CYP3A4 (0.41) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14967774 0.83 SMN1; SMN2 (0.36) SMN1; SMN2ALDH1A1OPRM1
SCHEMBL14968327 0.83 CYP3A4 (0.42) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD
SCHEMBL14967934 0.83 CYP3A4 (0.39) MAPTSMN1; SMN2ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US claimed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US claimed
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP disclosed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO disclosed