Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22347663 | 0.79 | HSD11B1 (0.39) | HSD11B1IDH1CHRM1KDM4ELMNA | |
| SCHEMBL14967862 | 0.72 | ERN1 (0.39) | KDM4EMEN1KMT2AMAPT | |
| SCHEMBL14968228 | 0.70 | IDH1 (0.35) | HSD11B1IDH1CHRM1KDM4EMEN1 | |
| SCHEMBL14881105 | 0.70 | CYP4F2 (0.43) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2445606 | 0.69 | NPSR1 (0.46) | HSD11B1IDH1CHRM1LMNAMEN1 | |
| SCHEMBL13736665 | 0.67 | NPSR1 (0.39) | HSD11B1IDH1CHRM1LMNAMAPT | |
| SCHEMBL24892085 | 0.67 | HSD11B1 (0.37) | HSD11B1IDH1CHRM1KDM4ELMNA | |
| SCHEMBL30182368 | 0.67 | HSD11B1 (0.37) | HSD11B1IDH1CHRM1KDM4ELMNA | |
| SCHEMBL22347341 | 0.67 | HSD11B1 (0.40) | HSD11B1IDH1CHRM1 | |
| SCHEMBL204803 | 0.66 | CHRM1 (0.39) | HSD11B1CHRM1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |