Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967411 | 0.78 | — | — | |
| SCHEMBL14968320 | 0.70 | HSD11B1 (0.35) | IDH1CHRM1HSD11B1KMT2AMEN1 | |
| SCHEMBL2445606 | 0.66 | NPSR1 (0.46) | IDH1CHRM1ALDH1A1HSD11B1KMT2A | |
| SCHEMBL29554681 | 0.65 | — | — | |
| SCHEMBL138336 | 0.65 | — | — | |
| SCHEMBL13736665 | 0.65 | NPSR1 (0.39) | IDH1CHRM1HSD11B1MAPT | |
| SCHEMBL30356803 | 0.63 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL7493214 | 0.63 | HSD11B1 (0.36) | IDH1CHRM1HSD11B1 | |
| SCHEMBL6120727 | 0.62 | LMNA (0.65) | ALDH1A1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL5845581 | 0.61 | MAPK1 (0.65) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |