Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967786 | 0.77 | ERN1 (0.45) | ERN1 | |
| SCHEMBL14967566 | 0.73 | ERN1 (0.47) | ERN1ALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL14968320 | 0.72 | HSD11B1 (0.35) | MAPTKDM4EMEN1KMT2A | |
| SCHEMBL15245235 | 0.71 | DGAT1 (0.41) | ERN1ALDH1A1MAPT | |
| SCHEMBL14969513 | 0.70 | ALDH1A1 (0.40) | ERN1ALDH1A1MAPTGRIN2BKDM4E | |
| SCHEMBL14969514 | 0.70 | ALDH1A1 (0.40) | ERN1ALDH1A1MAPTGRIN2BKDM4E | |
| SCHEMBL14968063 | 0.70 | ALDH1A1 (0.39) | ERN1ALDH1A1MAPTGRIN2BKDM4E | |
| SCHEMBL14968064 | 0.69 | ALDH1A1 (0.40) | ERN1ALDH1A1MAPTGRIN2BKDM4E | |
| SCHEMBL14968031 | 0.69 | ERN1 (0.46) | ERN1GRIN2BABL1PIK3CGPIK3CD | |
| SCHEMBL14967450 | 0.67 | ERN1 (0.35) | ERN1ALDH1A1MAPTGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |