⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759396 | 0.79 | CA1 (0.33) | — | |
| SCHEMBL15759431 | 0.79 | CA1 (0.30) | — | |
| SCHEMBL15759393 | 0.76 | CES2 (0.35) | — | |
| SCHEMBL9359033 | 0.74 | — | — | |
| SCHEMBL93927 | 0.74 | ALDH1A1 (0.44) | — | |
| SCHEMBL15759439 | 0.72 | RAPGEF4 (0.32) | — | |
| SCHEMBL15759435 | 0.72 | KMT2A (0.41) | — | |
| SCHEMBL26861265 | 0.71 | — | — | |
| SCHEMBL13462896 | 0.71 | — | — | |
| SCHEMBL570928 | 0.71 | PREP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249186-B2 | Cytotoxic peptides and antibody drug conjugates thereof | PFIZER INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150307551-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. | 2015-10-29 | — | — | US | disclosed |
| US-8828401-B2 | Cytotoxic peptides and antibody drug conjugates thereof | PFIZER INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8741291-B2 | Multifunctional antibody conjugates | COVX TECHNOLOGIES IRELAND, LIMITED (IE) | 2014-06-03 | — | — | US | disclosed |
| US-20130129753-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2013-05-23 | — | — | US | disclosed |