SCHEMBL1496858

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496842	0.95	KMT2A (0.40)	MEN1ALDH1A1KMT2ALMNASMN1; SMN2
	SCHEMBL3224939	0.94	MEN1 (0.42)	MEN1ALDH1A1KMT2ALMNASMN1; SMN2
	SCHEMBL1496905	0.92	ROCK2 (0.39)	ALDH1A1ROCK2PDCD1CD274ROCK1
	SCHEMBL12831865	0.92	ROCK2 (0.41)	ROCK2PDCD1CD274ROCK1CYP3A4
	SCHEMBL1496834	0.92	ROCK2 (0.46)	LMNASMN1; SMN2ROCK2PDCD1CD274
	SCHEMBL1496853	0.92	ROCK2 (0.49)	SMN1; SMN2ROCK2ROCK1CYP3A4CYP2D6
	SCHEMBL8004078	0.89	ROCK2 (0.42)	MEN1KMT2AROCK2PDCD1CD274
	SCHEMBL1497118	0.89	NAMPT (0.45)	ALDH1A1ROCK2PDCD1CD274ROCK1
	SCHEMBL3233986	0.89	HDAC1 (0.42)	MEN1ALDH1A1KMT2ALMNASMN1; SMN2
	SCHEMBL1497472	0.89	ROCK2 (0.39)	ROCK2PDCD1CD274ROCK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.