SCHEMBL14969500

SCHEMBL14969500

COc1ccc(C2(C(=O)Oc3ccccc3)OC23CCCCC3)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.52
TRPV1 Q8NER1 1/20 0.52
CTSK P43235 2/20 0.42
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
ALDH1A1 P00352 6/20 0.41
USP2 O75604 3/20 0.41
KDM4E B2RXH2 2/20 0.41
CYP2D6 P10635 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPK1 P28482 1/20 0.41
CYP2C19 P33261 3/20 0.40
CYP3A4 P08684 3/20 0.40
OPRM1 P35372 1/20 0.40
OPRL1 P41146 1/20 0.40
CYP2C9 P11712 3/20 0.39
HPGD P15428 2/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
EP300 Q09472 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14967817 0.99 FAAH (0.50) FAAHTRPV1CTSKSLC6A4SLC6A3
SCHEMBL14968020 0.96 FAAH (0.47) FAAHTRPV1CTSKALDH1A1USP2
SCHEMBL14967115 0.90 FAAH (0.43) FAAHTRPV1ALDH1A1KDM4EKMT2A
SCHEMBL14967781 0.89 FAAH (0.40) FAAHTRPV1USP2KDM4EPOLB
SCHEMBL14967038 0.88 POLB (0.42) FAAHTRPV1KDM4EPOLBL3MBTL1
SCHEMBL14967804 0.87 POLB (0.40) FAAHTRPV1ALDH1A1USP2KDM4E
SCHEMBL14967750 0.85 SLC6A4 (0.46) FAAHTRPV1SLC6A4SLC6A3ALDH1A1
SCHEMBL14968235 0.85 POLB (0.42) FAAHTRPV1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL14967569 0.85 POLB (0.40) FAAHTRPV1USP2KDM4ESMN1; SMN2
SCHEMBL14967509 0.84 KDM4E (0.46) FAAHTRPV1SLC6A4SLC6A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US claimed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US claimed
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP disclosed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO disclosed