SCHEMBL1496984

SCHEMBL1496984

CN(C)CCC(NC(=O)NCCc1ccccc1)c1ccc(C(=O)Nc2cscc2N)cc1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 19/20 0.49
HDAC1 Q13547 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2473139 0.89 HDAC1 (0.55) UTS2RHDAC1
SCHEMBL1483181 0.89 UTS2R (0.47) UTS2R
SCHEMBL10476414 0.86 UTS2R (0.46) UTS2R
SCHEMBL1497017 0.85 HIF1A (0.46) UTS2R
SCHEMBL1496894 0.84 UTS2R (0.46) UTS2RHDAC1
SCHEMBL1497005 0.84 UTS2R (0.42) UTS2RHDAC1
SCHEMBL2472961 0.84 HDAC1 (0.55) UTS2RHDAC1
SCHEMBL1496906 0.84 UTS2R (0.47) UTS2R
SCHEMBL1497026 0.81 POLB (0.45) HDAC1
SCHEMBL1497110 0.81 UTS2R (0.47) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2292611-B1 NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO LTD (JP) 2012-07-25 EP disclosed
EP-2292611-A1 NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE Santen Pharmaceutical Co., Ltd (JP) 2011-03-09 EP disclosed