SCHEMBL1497072

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1497058	0.92	HIF1A (0.44)	PDCD1CD274CNR1HDAC1ROCK1
	SCHEMBL12831708	0.92	PDCD1 (0.37)	PDCD1CD274HDAC1ROCK1HTR5A
	SCHEMBL1483172	0.91	HIF1A (0.42)	PDCD1CD274HDAC1ROCK1HTR5A
	SCHEMBL1496893	0.88	POLB (0.37)	PDCD1CD274CNR1HDAC1ROCK1
	SCHEMBL1497014	0.87	HIF1A (0.48)	HDAC1ROCK1HTR5AHDAC3HDAC2
	SCHEMBL1496888	0.87	ROCK1 (0.40)	PDCD1CD274CNR1HDAC1ROCK1
	SCHEMBL1496974	0.87	MEN1 (0.43)	PDCD1CD274HDAC1ROCK1HDAC3
	SCHEMBL8004129	0.87	ROCK2 (0.40)	PDCD1CD274HDAC1ROCK1HTR5A
	SCHEMBL8001271	0.86	HIF1A (0.41)	PDCD1CD274HDAC1ROCK1HTR5A
	SCHEMBL8004725	0.86	PDCD1 (0.37)	PDCD1CD274HDAC1ROCK1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.