SCHEMBL1496893

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496945	0.93	HIF1A (0.41)	PDCD1CD274RAF1CNR1ROCK1
	SCHEMBL1496862	0.92	HTR5A (0.40)	PDCD1CD274RAF1ROCK1HDAC1
	SCHEMBL12831883	0.91	RAF1 (0.37)	PDCD1CD274RAF1CNR1ROCK1
	SCHEMBL1497043	0.89	HIF1A (0.42)	HDAC1HTR5AROCK2
	SCHEMBL1496875	0.89	HTR5A (0.39)	POLBPDCD1CD274ROCK1HDAC1
	SCHEMBL1496860	0.89	ROCK2 (0.38)	PDCD1CD274RAF1ROCK1HDAC1
	SCHEMBL1496892	0.88	CTSK (0.38)	PDCD1CD274ROCK1HDAC1HTR5A
	SCHEMBL1496843	0.88	KMT2A (0.40)	RAF1CNR1ROCK1HDAC1MAPT
	SCHEMBL1497072	0.88	PDCD1 (0.38)	PDCD1CD274RAF1CNR1ROCK1
	SCHEMBL1496858	0.88	MEN1 (0.41)	POLBPDCD1CD274ROCK1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.