Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.80 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.70 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.70 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.70 |
| ▸ | MET | P08581 | 1/20 | 0.70 |
| ▸ | SPR | P35270 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15200278 | 0.94 | ALK (0.81) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL572281 | 0.92 | SPR (0.75) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL10270581 | 0.92 | SPR (0.75) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL10270813 | 0.91 | MAP3K7 (0.74) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL15199154 | 0.89 | ALK (0.85) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL27907079 | 0.89 | MAP3K7 (0.71) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL10270906 | 0.88 | MAP3K7 (0.72) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL29937816 | 0.88 | MAP3K7 (0.77) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL21026280 | 0.88 | MAP3K7 (0.77) | ALKMAP3K7IRAK4IRAK1MET | |
| SCHEMBL21026016 | 0.88 | MAP3K7 (0.77) | ALKMAP3K7IRAK4IRAK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046625-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046625-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2016-02-18 | — | — | US | disclosed |
| US-20150306086-A1 | MODULATING CERTAIN TYROSINE KINASES | TESARO, INC. | 2015-10-29 | — | — | US | disclosed |
| US-20150306086-A1 | MODULATING CERTAIN TYROSINE KINASES | TESARO, INC. | 2015-10-29 | — | — | US | disclosed |
| US-9115127-B2 | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase | AMGEN INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115127-B2 | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase | AMGEN INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-20130217668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| CN-103168032-A | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase | AMGEN INC | 2013-06-19 | — | — | CN | disclosed |
| WO-2013074518-A1 | MODULATING CERTAIN TYROSINE KINASES | TESARO, INC. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046625-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | BCL6, DCK, FLI1 | ALK 8/4885MAP3K7 71/4885IRAK4 534/4885 |
| US-20150306086-A1 | MODULATING CERTAIN TYROSINE KINASES | ABL1, LCK, FLT3 | ALK 53/4885MAP3K7 114/4885IRAK4 205/4885 |
| US-20130217668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | BCL6, DCK, FLI1 | ALK 8/4885MAP3K7 71/4885IRAK4 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.