SCHEMBL149728

SCHEMBL149728

C#Cc1ccccc1CO

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
APOBEC3G Q9HC16 1/20 0.43
FFAR1 O14842 1/20 0.40
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
TSHR P16473 1/20 0.35
CYP2A6 P11509 1/20 0.34
PDK2 Q15119 1/20 0.34
CYP1A1 P04798 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP1B1 Q16678 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
HPGD P15428 2/20 0.32
PYCR1 P32322 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HSPA5 P11021 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5403277 0.94 APOBEC3G (0.39) APOBEC3GFFAR1PDCD1CD274TSHR
Pyridine SCHEMBL1220102 0.87 FFAR1 (0.37) APOBEC3GFFAR1PDCD1CD274TSHR
SCHEMBL5750300 0.81 APOBEC3G (0.43) APOBEC3GFFAR1PDCD1CD274TSHR
SCHEMBL3037715 0.80 APOBEC3G (0.34) APOBEC3GFFAR1PDCD1CD274
SCHEMBL9862093 0.80 HSPA5 (0.40) CYP1A1CYP1A2CYP1B1PYCR1HSPA5
SCHEMBL15000783 0.79 PTGDR2 (0.41) APOBEC3GFFAR1PDCD1CD274PDK2
SCHEMBL13821279 0.79 KDM4E (0.36) FFAR1CYP1A2SLC6A4ALDH1A1
SCHEMBL4170188 0.78 TRPA1 (0.36) TSHRCYP1A1CYP1A2CYP1B1PYCR1
SCHEMBL1253891 0.76 CYP1A1 (0.33) CYP1A1CYP1A2CYP1B1PYCR1
SCHEMBL21410141 0.76 APOBEC3G (0.43) APOBEC3GFFAR1PDCD1CD274TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11263787-A None JP disclosed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US disclosed
CN-117000164-A Method for preparing alkynol by applying micro-channel reactor to liquid ammonia/acetylene system 日照盛泉新材料科技有限公司 2023-11-07 CN disclosed
CN-117003760-A Preparation method of quinoline condensed ring derivative 广东工业大学 2023-11-07 CN disclosed
CN-114853556-B New synthesis method of 5H-dibenzo [ a, d ] cycloheptene skeleton 绍兴文理学院 2023-08-29 CN disclosed
EP-3625218-B1 PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2023-03-01 EP disclosed
US-11584773-B2 Phosphorous protecting groups and methods of preparation and use thereof AGILENT TECHNOLOGIES, INC. (US) 2023-02-21 US disclosed
CN-114907389-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-08-16 CN disclosed
CN-114853556-A Novel synthesis method of 5H-dibenzo [ a, d ] cycloheptene skeleton 绍兴文理学院 2022-08-05 CN disclosed
US-20220056167-A1 Functionalized Cyclic Polymers and Methods of Preparing Same NATIONAL SCIENCE FOUNDATION 2022-02-24 US disclosed
CN-1665780-A Tricyclic steroid hormone nuclear receptor modulators LILLY CO ELI (US) 2005-09-07 CN disclosed
EP-1519915-A2 TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2005-04-06 EP disclosed
WO-2004052847-A2 TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2004-06-24 WO disclosed
CN-1124260-C Para retinoic acid HOFFMANN LA ROCHE (CH) 2003-10-15 CN disclosed
US-5986131-A UNSATURATED CARBOXYLIC ACID DERIVATIVES AS LIGANDS AND RETINOIC ACID RECEPTORS HOFFMANN-LA ROCHE INC. (US) 1999-11-16 US disclosed
EP-0728742-B1 Novel retinoids HOFFMANN LA ROCHE (CH) 1999-10-20 EP disclosed
JP-H11263787-A PRODUCTION OF ISOCHROMANONE DERIVATIVE JAPAN SCIENCE & TECHNOLOGY CORP 1999-09-28 JP disclosed
CN-1136557-A Para retinoic acid HOFFMANN LA ROCHE (CH) 1996-11-27 CN disclosed
EP-0728742-A2 Novel retinoids F. HOFFMANN-LA ROCHE AG (CH) 1996-08-28 EP disclosed
EP-0061713-B1 CYCLOPROPANECARBOXYLIC ACID ESTERS, THEIR PRODUCTION AND INSECTICIDAL AND ACARICIDAL COMPOSITIONS CONTAINING THEM SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-11-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11584773-B2 Phosphorous protecting groups and methods of preparation and use thereof POLN, POLRMT, NUDT21 APOBEC3G 392/4885FFAR1 4683/4885PDCD1 2141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.