Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973170 | 0.88 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14973279 | 0.86 | RAB9A (0.49) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14973098 | 0.85 | CA12 (0.51) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14973156 | 0.85 | MEN1 (0.45) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2826141 | 0.79 | MAPT (0.46) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14938263 | 0.75 | NTRK1 (0.43) | RAB9ANPC1ALDH1A1KDM4EHPGD | |
| SCHEMBL8343590 | 0.74 | MAPT (0.60) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15750737 | 0.74 | ALDH1A1 (0.56) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11890412 | 0.73 | ALDH1A1 (0.71) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8345184 | 0.73 | TRPC1 (0.67) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137865-A1 | HETEROARYL-PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137865-A1 | HETEROARYL-PYRAZOLE DERIVATIVE | GRIN2C, GRIN2B, GRIN3A | MAPT 129/4885RAB9A 1090/4885NPC1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.