Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21792658 | 0.86 | KMT2A (0.63) | ALDH1A1KMT2AMEN1ATMLMNA | |
| SCHEMBL2932454 | 0.83 | L3MBTL1 (0.54) | KDM4EALDH1A1KMT2AMEN1ATM | |
| SCHEMBL2396520 | 0.79 | VEGFA (0.50) | KMT2AMEN1ATMMAPTPOLB | |
| SCHEMBL13150240 | 0.79 | KMT2A (0.52) | KDM4EALDH1A1KMT2AMEN1ATM | |
| SCHEMBL20570029 | 0.78 | ATM (0.47) | KDM4EALDH1A1KMT2AMEN1ATM | |
| SCHEMBL31277423 | 0.78 | HRH3 (0.56) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL2931705 | 0.78 | AKR1C3 (0.65) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL5571317 | 0.78 | LMNA (0.46) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL23617943 | 0.78 | KMT2A (0.58) | KDM4EALDH1A1KMT2AMEN1ATM | |
| SCHEMBL2850013 | 0.78 | ALDH1A1 (0.70) | KDM4EALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475375-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011031896-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |