Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Clinafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.96 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | POLB | P06746 | 2/20 | 0.96 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.96 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 9/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TOP1 | P11387 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clinafloxacin SCHEMBL33959 | 0.98 | ALDH1A1 (1.00) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL8596801 | 0.98 | ALDH1A1 (1.00) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL33960 | 0.98 | ALDH1A1 (1.00) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL29360508 | 0.98 | ALDH1A1 (1.00) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL193234 | 0.97 | ALDH1A1 (0.98) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL193233 | 0.97 | ALDH1A1 (0.98) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL29288561 | 0.97 | ALDH1A1 (0.98) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL5571098 | 0.97 | ALDH1A1 (0.98) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL29682535 | 0.97 | ALDH1A1 (0.98) | ALDH1A1POLBOPRM1CHRM2CHRM1 | |
| Clinafloxacin SCHEMBL8566142 | 0.94 | ALDH1A1 (0.93) | ALDH1A1POLBOPRM1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |