Clinafloxacin

Clinafloxacin

SCHEMBL29360508

NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 1.00
POLB P06746 2/20 1.00
OPRM1 P35372 2/20 1.00
CHRM2 P08172 1/20 1.00
CHRM1 P11229 1/20 1.00
OPRD1 P41143 1/20 1.00
KCNH2 Q12809 4/20 0.61
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
TOP2A P11388 9/20 0.56
TOP2B Q02880 7/20 0.56
KDM4E B2RXH2 1/20 0.55
PRKD3 O94806 1/20 0.55
HPGD P15428 1/20 0.55
ALOX15 P16050 1/20 0.55
CLK2 P49760 1/20 0.55
HSD17B10 Q99714 1/20 0.55
CLK4 Q9HAZ1 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
TOP1 P11387 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clinafloxacin SCHEMBL8596801 1.00 ALDH1A1 (1.00) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL33959 1.00 ALDH1A1 (1.00) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL33960 1.00 ALDH1A1 (1.00) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL29682535 0.99 ALDH1A1 (0.98) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL5571098 0.99 ALDH1A1 (0.98) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL193234 0.99 ALDH1A1 (0.98) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL193233 0.99 ALDH1A1 (0.98) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL29288561 0.99 ALDH1A1 (0.98) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL14973954 0.98 ALDH1A1 (0.96) ALDH1A1POLBOPRM1CHRM2CHRM1
Clinafloxacin SCHEMBL8566142 0.96 ALDH1A1 (0.93) ALDH1A1POLBOPRM1CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4434588-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2026-04-08 EP claimed
EP-3711797-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2025-02-12 EP claimed
EP-4434588-A2 AEROSOL DELIVERY DEVICE AND METHOD OF OPERATING THE AEROSOL DELIVERY DEVICE PARI Pharma GmbH (DE) 2024-09-25 EP claimed
EP-3122757-B1 CHARGED LINKERS AND THEIR USES FOR CONJUGATION HANGZHOU DAC BIOTECH CO LTD (CN) 2023-09-06 EP claimed
WO-2022166129-A1 SCREENING METHOD FOR HETEROLOGOUS COMPETITIVE ANTIGEN FOR USE IN IMPROVEMENT OF IMMUNODETECTION SENSITIVITY 江西煌上煌集团食品股份有限公司 2022-08-11 WO claimed
EP-3265083-B1 SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE ST JUDE CHILDRENS RES HOSPITAL (US) 2022-07-06 EP claimed
EP-4434588-B1 AEROSOL DELIVERY DEVICE PARI PHARMA GMBH (DE) 2026-04-08 EP disclosed
EP-4713056-A1 DEVICE FOR PROVIDING CONTINUED BREATH GUIDANCE, METHOD OF OPERATING AN INHALATION DEVICE, INHALATION DEVICE AND INHALATION DEVICE SYSTEM FOR PROVIDING INHALATION PROCESS/BREATH GUIDING Pari Medical Holding GmbH (DE) 2026-03-25 EP disclosed
EP-4712837-A1 METHOD OF OPERATING AN INHALATION DEVICE, INHALATION DEVICE, INHALATION DEVICE SYSTEM FOR PROVIDING INHALATION PROCESS FEEDBACK AND DEVICE FOR PROVIDING FEEDBACK GUIDANCE Pari Medical Holding GmbH (DE) 2026-03-25 EP disclosed
US-12558353-B2 Method of reducing pulmonary exacerbations in respiratory disease patients CELLTAXIS, LLC (US) 2026-02-24 US disclosed
EP-4659255-A1 MEDICAL EVALUATION METHOD, AEROSOL NEBULIZER AND MEDICAL EVALUATION SYSTEM Pari Medical Holding GmbH (DE) 2025-12-10 EP disclosed
US-20250347055-A1 WATER RESISTANT MATERIALS FOR FOOD-SAFE USES JL DARLING LLC (US) 2025-11-13 US disclosed
US-12404635-B2 Water resistant materials for food-safe uses JL DARLING LLC (US) 2025-09-02 US disclosed
WO-2022166129-A1 SCREENING METHOD FOR HETEROLOGOUS COMPETITIVE ANTIGEN FOR USE IN IMPROVEMENT OF IMMUNODETECTION SENSITIVITY 江西煌上煌集团食品股份有限公司 2022-08-11 WO disclosed
WO-2022155495-A1 METHODS FOR OPTIMIZING CFTR-MODULATOR THERAPY CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2022-07-21 WO disclosed
US-20220218834-A1 APOHEMOGLOBIN-HAPTOGLOBIN COMPLEXES AND METHODS OF USING THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-07-14 US disclosed
EP-4003200-A1 ANTIBACTERIAL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS USING SAME The Rockefeller University (US) 2022-06-01 EP disclosed
WO-2022081867-A1 COMPOSITIONS AND METHODS FOR DRUG DELIVERY NORTH CAROLINA STATE UNIVERSITY (US) 2022-04-21 WO disclosed
EP-3972646-A1 APOHEMOGLOBIN-HAPTOGLOBIN COMPLEXES AND METHODS OF USING THEREOF Ohio State Innovation Foundation (US) 2022-03-30 EP disclosed
WO-2022016216-A1 BIOCOMPATIBLE POLYMER COMPOSITIONS THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2022-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12558353-B2 Method of reducing pulmonary exacerbations in respiratory disease patients SERPINB1, CFTR, LTA4H ALDH1A1 881/4885POLB 2742/4885OPRM1 4301/4885
US-20220218834-A1 APOHEMOGLOBIN-HAPTOGLOBIN COMPLEXES AND METHODS OF USING THEREOF HBG1, HBG2, LPO ALDH1A1 3209/4885POLB 1274/4885OPRM1 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.