SCHEMBL1497425

SCHEMBL1497425

CC(C)(C)OC(=O)NCC12CC3CC(C1)C(=O)C(C3)C2

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.47
MAPT P10636 1/20 0.45
EPHX2 P34913 7/20 0.44
ALDH1A1 P00352 3/20 0.43
TSHR P16473 1/20 0.43
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPK1 P28482 1/20 0.41
LMNA P02545 1/20 0.40
CACNA1H O95180 1/20 0.40
P2RX7 Q99572 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1497427 1.00 HSD17B10 (0.47) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL1497403 0.80 MAPT (0.46) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL14330188 0.80 ALDH1A1 (0.41) HSD17B10EPHX2ALDH1A1TSHRMEN1
SCHEMBL1497402 0.78 MAPT (0.48) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL1497400 0.78 MAPT (0.45) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL1497409 0.77 HSD11B1 (0.46) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL2719172 0.76 EPHX2 (0.62) EPHX2MEN1KMT2AMAPK1CACNA1H
SCHEMBL12861262 0.76 EPHX2 (0.62) EPHX2MEN1KMT2AMAPK1CACNA1H
SCHEMBL12759018 0.75 MAPT (0.42) HSD17B10MAPTEPHX2ALDH1A1TSHR
SCHEMBL1497438 0.75 MAPT (0.42) HSD17B10MAPTEPHX2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8440720-B2 Methods of use of antiviral compounds INFLUMEDIX, INC. (US) 2013-05-14 US disclosed
US-8440720-B2 Methods of use of antiviral compounds INFLUMEDIX, INC. (US) 2013-05-14 US disclosed
US-8440720-B2 Methods of use of antiviral compounds INFLUMEDIX, INC. (US) 2013-05-14 US disclosed
US-20110065766-A1 METHODS OF USE OF ANTIVIRAL COMPOUNDS INFLUMEDIX, INC. 2011-03-17 US disclosed
US-20110065766-A1 METHODS OF USE OF ANTIVIRAL COMPOUNDS INFLUMEDIX, INC. 2011-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065766-A1 METHODS OF USE OF ANTIVIRAL COMPOUNDS MAVS, SLC30A5, HAVCR2 HSD17B10 3104/4885MAPT 3781/4885EPHX2 3743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.