Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 6/20 | 0.42 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22153160 | 0.89 | CTSS (0.53) | MMP2SYKCTSSCTSK | |
| SCHEMBL13821639 | 0.88 | CTSS (0.54) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL13821708 | 0.88 | GAA (0.51) | MMP2MAPTPPARGPPARASYK | |
| SCHEMBL2548981 | 0.87 | MMP2 (0.58) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL3604545 | 0.87 | MMP2 (0.58) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL2548977 | 0.87 | MMP2 (0.58) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL13821434 | 0.85 | CTSS (0.58) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL13821570 | 0.85 | CYP17A1 (0.48) | MMP2SYKATMCTSSCTSK | |
| SCHEMBL13821710 | 0.84 | POLB (0.47) | MMP2MAPTSYKATMCTSS | |
| SCHEMBL21447461 | 0.84 | OPRM1 (0.53) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782917-A1 | THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C | Cancer Research Technology Limited (GB) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078126-A1 | THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2013-05-30 | — | — | WO | disclosed |