Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975426 | 0.90 | MET (0.36) | METKCNQ3KCNQ2KDRLCK | |
| SCHEMBL14975604 | 0.88 | AXL (0.46) | METKDRRIPK3RIPK1AXL | |
| SCHEMBL14975335 | 0.86 | AXL (0.47) | METKDRRIPK3RIPK1AXL | |
| SCHEMBL14977826 | 0.84 | MET (0.34) | METKCNQ3KCNQ2KDRLCK | |
| SCHEMBL16059291 | 0.82 | MET (0.35) | METKDRRIPK3RIPK1LCK | |
| SCHEMBL14975389 | 0.79 | MET (0.46) | METKDRAXLTYRO3MERTK | |
| SCHEMBL14975552 | 0.78 | MET (0.44) | METKDRRIPK3RIPK1AXL | |
| SCHEMBL14975545 | 0.77 | MET (0.47) | METKDRRIPK3RIPK1AXL | |
| SCHEMBL14975035 | 0.77 | MET (0.42) | METKDRAXLSCN8ASCN10A | |
| SCHEMBL14975314 | 0.76 | KDR (0.48) | METKDRRIPK3RIPK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782577-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, LLC. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078295-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2013-05-30 | — | — | WO | disclosed |