Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137048 | 0.83 | MET (0.40) | METKDM4EKDRGCKRAB9A | |
| SCHEMBL14975426 | 0.83 | MET (0.36) | METKDRLCKKITFLT3 | |
| SCHEMBL14975674 | 0.82 | MET (0.38) | METRIPK3RIPK1RIPK2KDR | |
| SCHEMBL2588943 | 0.79 | MET (0.36) | METKDM4EGAARIPK3RIPK1 | |
| SCHEMBL14977826 | 0.77 | MET (0.34) | METKDRLCKKITFLT3 | |
| SCHEMBL139824 | 0.74 | MET (0.41) | METRIPK3RIPK2KDRLCK | |
| SCHEMBL14975764 | 0.71 | MET (0.43) | METBRAFKDRNTRK1TEK | |
| SCHEMBL14975552 | 0.71 | MET (0.44) | METBRAFRIPK3RIPK1RIPK2 | |
| SCHEMBL14975863 | 0.70 | MET (0.42) | METBRAFKDRNTRK1TEK | |
| SCHEMBL14975545 | 0.70 | MET (0.47) | METRIPK3RIPK1RIPK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145004-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2014-09-18 | — | — | WO | disclosed |