Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496358 | 0.94 | CHEK1 (0.36) | MEN1ALDH1A1KMT2ASCN9ACHEK1 | |
| SCHEMBL495857 | 0.92 | MEN1 (0.31) | MEN1ALDH1A1KMT2ASCN9ACHEK1 | |
| SCHEMBL496465 | 0.87 | MEN1 (0.41) | MEN1ALDH1A1KMT2APGRNR3C2 | |
| SCHEMBL495888 | 0.87 | MEN1 (0.41) | MEN1ALDH1A1KMT2APGRNR3C2 | |
| SCHEMBL4368419 | 0.77 | FER (0.36) | MEN1KMT2ACTSKCHEK1RPS6KA3 | |
| SCHEMBL496194 | 0.74 | CHEK1 (0.40) | ALDH1A1CHEK1RPS6KA3SRPK1PGR | |
| SCHEMBL14976231 | 0.73 | JAK3 (0.42) | CHEK1RPS6KA3SRPK1IRAK4 | |
| SCHEMBL14638383 | 0.71 | AR (0.45) | PGRNR3C2ARCYP2D6CYP2C9 | |
| SCHEMBL17745697 | 0.71 | JAK2 (0.33) | ARIRAK4 | |
| SCHEMBL496442 | 0.68 | FER (0.34) | MEN1KMT2ACHEK1RPS6KA3SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955697-B1 | 2-AMINOBENZAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) INHIBITORS USEFUL FOR THE TREATMENT OF PAIN OR BLADDER FUNCTION DISORDER | ASTELLAS PHARMA INC (JP) | 2012-05-02 | — | — | EP | disclosed |
| US-8106190-B2 | 2-aminobenzamide derivatives | ASTELLAS PHARMA INC. (JP) | 2012-01-31 | — | — | US | disclosed |
| EP-1955697-A1 | 2-AMINOBENZAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-08-13 | — | — | EP | disclosed |