Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20354773 | 0.84 | HTR6 (0.39) | MTNR1AMTNR1BHTR6MEN1KMT2A | |
| SCHEMBL24583097 | 0.80 | BRD4 (0.45) | BRD4HTR6MEN1KMT2ACYP2C19 | |
| SCHEMBL15778909 | 0.78 | BRD4 (0.60) | BRD4 | |
| SCHEMBL1963075 | 0.77 | CYP2C19 (0.57) | BRD4HTR6MEN1KMT2APOLB | |
| SCHEMBL24584311 | 0.76 | BRD4 (0.43) | BRD4HTR6MEN1KMT2APOLB | |
| SCHEMBL1268099 | 0.76 | BRD4 (0.58) | BRD4HTR6MEN1KMT2APOLB | |
| SCHEMBL25158089 | 0.74 | BRD4 (0.47) | BRD4HTR6MEN1KMT2ACYP2C19 | |
| SCHEMBL1267767 | 0.73 | CYP2C19 (0.56) | BRD4HTR6L3MBTL1CYP2C19LMNA | |
| SCHEMBL1050209 | 0.72 | BRD4 (0.43) | BRD4HTR6MEN1KMT2APOLB | |
| SCHEMBL2110804 | 0.72 | BRD4 (0.43) | BRD4HTR6MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| EP-2794602-A1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | TBK1, NFKBIA, IKBKG | MTNR1A 3287/4885MTNR1B 3765/4885BRD4 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.