Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.42 |
| ▸ | TTK | P33981 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MST1R | Q04912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719094 | 0.82 | GSK3B (0.43) | RETTTKGSK3BDYRK1AGPR119 | |
| SCHEMBL15257727 | 0.81 | RET (0.46) | RETTTKGSK3BDYRK1AGPR119 | |
| SCHEMBL18437202 | 0.80 | GSK3B (0.41) | RETTTKGSK3BDYRK1AGPR119 | |
| SCHEMBL3804479 | 0.76 | GSK3B (0.41) | RETTTKGSK3BDYRK1AGPR119 | |
| SCHEMBL9887901 | 0.72 | PDPK1 (0.41) | METMST1R | |
| SCHEMBL12501035 | 0.72 | DDB1 (0.41) | GPR119MAPK1 | |
| SCHEMBL13554546 | 0.72 | RET (0.42) | RETTTKGSK3BDYRK1AGPR119 | |
| SCHEMBL18534361 | 0.71 | MET (0.36) | GSK3BDYRK1AABL1NTRK1YES1 | |
| SCHEMBL15257731 | 0.69 | FGFR2 (0.42) | METMST1R | |
| SCHEMBL12291796 | 0.69 | MKNK1 (0.37) | RETABL1MAPK1AURKBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| EP-2794602-A1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | TBK1, NFKBIA, IKBKG | RET 1449/4885TTK 1452/4885GSK3B 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.