Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PKLR | P30613 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976775 | 0.88 | HTR6 (0.53) | HTR6PKMSMN1; SMN2LMNAKMT2A | |
| SCHEMBL14976040 | 0.85 | HDAC3 (0.47) | HTR6PKMSMN1; SMN2LMNAKMT2A | |
| SCHEMBL14976807 | 0.84 | CA12 (0.49) | SMN1; SMN2LMNAKMT2AMEN1MAPT | |
| SCHEMBL14976472 | 0.84 | CACNA1B (0.43) | HTR6SMN1; SMN2HTTGAA | |
| SCHEMBL14977421 | 0.81 | HSD17B2 (0.52) | HTR6PKMKMT2AMAPTGAA | |
| SCHEMBL14976733 | 0.80 | HTR7 (0.47) | HTR6KMT2AALDH1A1 | |
| SCHEMBL16863962 | 0.73 | KMT2A (0.68) | PKMPKLRATMSMN1; SMN2LMNA | |
| SCHEMBL3153253 | 0.71 | HTR6 (1.00) | HTR6PKMPKLRATMSMN1; SMN2 | |
| SCHEMBL3152299 | 0.71 | HTR6 (1.00) | HTR6PKMPKLRATM | |
| SCHEMBL9942088 | 0.71 | ATM (0.72) | PKMPKLRATMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013076590-A1 | BENZOTHIAZINE COMPOUNDS AS H3 RECEPTOR LIGANDS | OXYGEN HEALTHCARE RESEARCH PVT. LTD (IN) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013076590-A1 | BENZOTHIAZINE COMPOUNDS AS H3 RECEPTOR LIGANDS | OXYGEN HEALTHCARE RESEARCH PVT. LTD (IN) | 2013-05-30 | — | — | WO | disclosed |