Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8832049 | 0.78 | ALDH1A1 (0.50) | RAD52LMNAKDM4EALDH1A1GAA | |
| SCHEMBL24254666 | 0.77 | KDM4E (0.36) | RAD52LMNAKDM4EALDH1A1GAA | |
| SCHEMBL3593722 | 0.73 | PDK2 (0.38) | RAD52LMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL5607858 | 0.72 | MAOA (0.33) | KDM4EALDH1A1GAAMAPTCD44 | |
| SCHEMBL18403260 | 0.68 | RAD52 (0.39) | RAD52LMNAKDM4EALDH1A1GAA | |
| SCHEMBL3171835 | 0.68 | RAD52 (0.55) | RAD52KDM4EALDH1A1GAAMAPT | |
| SCHEMBL3597817 | 0.67 | BRD4 (0.37) | ALDH1A1 | |
| SCHEMBL1119036 | 0.67 | GAA (0.46) | LMNAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL10757713 | 0.64 | NOS2 (0.38) | RAD52KDM4EALDH1A1GAAMAPT | |
| SCHEMBL29789724 | 0.64 | NOS2 (0.38) | RAD52KDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |