Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977695 | 0.88 | SYK (0.67) | SYKZAP70KCNH2AURKB | |
| SCHEMBL16100226 | 0.81 | SYK (0.66) | SYKZAP70KCNH2AURKB | |
| SCHEMBL14977487 | 0.78 | SYK (0.67) | SYK | |
| SCHEMBL14977815 | 0.77 | STAT6 (0.59) | SYKZAP70KCNH2AURKB | |
| SCHEMBL14977422 | 0.77 | SYK (0.62) | SYK | |
| SCHEMBL1354438 | 0.76 | SYK (0.73) | SYK | |
| SCHEMBL1354443 | 0.76 | SYK (0.73) | SYK | |
| SCHEMBL14976632 | 0.75 | SYK (0.76) | SYKKCNH2AURKB | |
| SCHEMBL14976634 | 0.75 | SYK (0.76) | SYKKCNH2AURKB | |
| SCHEMBL1351796 | 0.74 | SYK (1.00) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |